Matthew Cooperberg graduated from Dartmouth College, where he finished summa cum laude with a major in English. He earned his MD and MPH degrees at Yale University, and completed residency in Urology and fellowship in Urologic Oncology at UCSF. At the end of his training, Dr. Cooperberg joined the faculty at UCSF. He is Chief of Urology at the San Francisco VA Medical Center, and he maintains busy clinical practices both there and at the UCSF Helen Diller Family Comprehensive Cancer Center, where is the Urology co-Leader of the Prostate Program. He also holds a secondary appointment in the Department of Epidemiology & Biostatistics.

他积极从事从分子分析到卫生系统研究等多个相关角度应对前列腺癌挑战的研究。他撰写或贡献了400多篇研究文章。2013年初，Cooperberg博士与人合著了一份国家泌尿学注册的提案，作为AUA质量(AQUA)注册的基础，他现在担任该项目的高级医师顾问。2015年，他获得了AUA金膀胱镜奖，并于2016年获得了他作为美国国家癌症研究所首席研究员的第一笔R01奖，用于开发和验证新的基于mirna的生物标志物，用于精细的前列腺癌预后。

He lives in San Francisco with his wife, Jacqueline Dolev (a dermatologist and fellow Yale Medical School alum), where they work primarily to keep up with their children, Jake and Sarah.